It is extensive, included only placebo controlled double blind trials and searched successfully for unpublished trials.ĭepression is a common condition, affecting an estimated 1 in 10 adults at some point in their lives. Though there are some concerns over items not reported by individual trials, this review is likely to be reliable. However, it did not assess antidepressants compared to other treatments such as cognitive behavioural therapy, or treatments in combination.
The review provides new evidence which may help people decide which antidepressant to choose first-line for moderate to severe depression. Several drugs were more effective and were stopped by fewer people than others: Researchers ranked drugs by effectiveness and acceptability after eight weeks of treatment. Five antidepressants appear more effective and better tolerated than others.Ī major review of 522 antidepressant trials found that all of the 21 drugs studied performed better than placebo, in short-term trials measuring response to treatment.
This is a plain English summary of an original research articleĪntidepressants are effective to treat moderate to severe depression in adults.
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